Causes of Congenital Cataract
- Prenatal (intra-uterine) infection e.g. rubella, cytomegalovirus, syphilis.
- Prenatal (intra-uterine) drug exposure e.g. corticosteroids, vitamin A.
- Prenatal (intra-uterine) ionizing radiation e.g. x-rays.
- Prenatal / peri-natal metabolic disorder e.g. maternal diabetes.
- Hereditary (isolated - without associated eye or systemic disorder) e.g. autosomal dominant inheritance.
- Hereditary with associated systemic disorder or multi-system syndrome.
a) Chromosomal e.g. Down’s syndrome (trisomy 21), Turner’s syndrome.
b) With skeletal disease or muscle disorder e.g. Stickler syndrome, Myotonic dystrophy.
c) With central nervous system disorder e.g. Norrie’s disease.
d) With renal disease e.g. Lowe’s syndrome, Alport’s syndrome.
e) With mandibulo-facial disorder e.g. Nance-Horan cataract-dental syndrome.
f) With dermatological disorder e.g. Congenital icthyosis, Incontinentia pigmenti.
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