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Sunday, February 15, 2009

Disulfiram reaction & Other drugs causing it.

490024328_323fa90acaAlcohol intake is strictly prohibited when we take these drugs!Let us know what these drugs are.

 

First lets know something about Disulfiram.

antabusebig

Disulfiram (Antabuse), is an aversive agent that inhibits the metabolism of alcohol. The usual dose of disulfiram is 250 mg once daily.

 

Disulfiram is an irreversible and nonspecific enzyme-inhibitory agent which inhibits the enzyme acetaldehyde-dehydrogenase (ALDH),leading to an accumulation of acetaldehyde in the body ,leading to the ethanol-disulfiram reaction.

Formula_acetaldehyde Disulfiram irreversibly inhibits the oxidation of acetaldehyde by competing with the cofactor nicotinamide adenine dinucleotide (NAD) for binding sites on ALDH . Ultimately, disulfiram reduces the rate of oxidation of acetaldehyde, causing a 5- to 10-fold increase in the concentration of acetaldehyde. An increased serum acetaldehyde concentration is thought to be responsible for the unpleasant side effects associated with the disulfiram-ethanol reaction.source:medscape

 756148-814525-35

The disulfiram-ethanol reaction (DER) is the classic manifestation of patients with disulfiram toxicity. This reaction occurs after the ingestion of even small amounts of ethanol with the concomitant use of disulfiram or disulfiram-like agents.

Disulfiram-ethanol reaction:

  • Head, neck, and chest flushing - Histamine-induced vasodilation
  • Throbbing headaches
  • Nausea, vomiting (may be refractory), diarrhea, and abdominal pain
  • Weakness, dizziness, confusion, and anxiety
  • Vertigo and ataxia
  • Orthostatic hypotension - Hypotensive flushing reaction with warm extremities
  • Diaphoresis
  • Palpitations and dysrhythmias
  • Pruritus
  • Refractory cyanosis (eg, methemoglobinemia)

 

Drugs that may produce disulfiramlike reactions with ethanol include the following:

  • Mushrooms (eg, Coprinus atramentarius [inky cap], Clitocybe claviceps)
  • Antibiotics
  1. metronidazole,Tinidazole is chemically similar to metronidazole and so may cause the same reaction
  2. sulfonamides(trimethoprim-sulfamethoxazole)
  3. some cephalosporins( eg: cephamandole, cefoperazone, cefmenoxime, cefotetan, Moxalactam)- due to METHYLTETRAZOLETHIOL side chain.
  4. nitrofurantoin,
  5. chloramphenicol
  6. furazolidine
  7. Antimalarial Quinacrine
  • Oral hypoglycemics (eg: chlorpropamide, tolbutamide)- these sulphonylureas compete with acetaldehyde for binding sites on ALDH.
  • Pesticides (eg: carbamates, monosulfiram [Tetmosol])
  • Chloral hydrate
  • Antifungals (griseofulvin)

19 comments:

Anonymous said...

i am wondering if anyone out there is taking Disulfirum, so that I can get some education (lamen terms) on the do's and don'ts before i begin my prescription?

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Unknown said...

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Lilian Wale said...

There are some natural remedies that can be used in the prevention and eliminate diabetes totally. However, the single most important aspect of a diabetes control plan is adopting a wholesome life style Inner Peace, Nutritious and Healthy Diet, and Regular Physical Exercise. A state of inner peace and self-contentment is essential to enjoying a good physical health and over all well-being. The inner peace and self contentment is a just a state of mind.People with diabetes diseases often use complementary and alternative medicine. I diagnosed diabetes in 2013. Was at work feeling unusually tired and sleepy. I borrowed a glucometer from a co-worker and tested at 760. Went immediately to my doctor and he gave me prescription like: Insulin ,Sulfonamides, but I could not get the cure rather to reduce the pain and brink back the pain again. I found a woman testimony name Comfort online how Dr Akhigbe cure her HIV  and I also contacted the doctor and after I took his medication as instructed, I am now completely free from diabetes by doctor Akhigbe herbal medicine.So diabetes patients reading this testimony to contact his email     drrealakhigbe@gmail.com   or his Number   +2348142454860   He also use his herbal herbs to diseases like:SPIDER BITE, SCHIZOPHRENIA, LUPUS,EXTERNAL INFECTION, COMMON COLD, JOINT PAIN, BODY PAIN, EPILEPSY,STROKE,TUBERCULOSIS ,STOMACH DISEASE. ECZEMA, PROGERIA, EATING DISORDER, LOWER RESPIRATORY INFECTION, MALARIA, BACTERIA DIARRHEA, DENGUE FEVER, HERPATITIS A&B, RABIES DIABETICS,HERPES,HIV/AIDS, ;ALS,  CANCER , ARTHRITIS,  BREAST INFECTION, MENINGITIS,HEPATITIS A AND B, THYROID, ASTHMA, HEART DISEASE, CHRONIC DISEASE. AUTISM, NAUSEA VOMITING OR DIARRHEA,KIDNEY DISEASE, WEAK ERECTION. EYE TWITCHING PAINFUL OR IRREGULAR MENSTRUATION.Dr Akhigbe is a good man and he heal any body that come to him. here is email    drrealakhigbe@gmail.com    and his Number +2349010754824

Suntran Matthew said...

I am here to give my testimony about Dr Ebhota who helped me.. i want to inform the public how i was cured from (HERPES SIMPLEX VIRUS) by salami, i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how Dr Ehbota cured them. when i contacted him he gave me hope and send a Herbal medicine to me that i took for just 2 weeks and it seriously worked for me, my HERPES result came out negative. I am so happy as i am sharing this testimony. My advice to you all who thinks that there is no cure for herpes that is Not true just contact him and get cure from Dr Ebhota healing herbal cure of all kinds of sickness you may have like
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Crystal Joseph said...

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juwan james said...

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Isaac larry said...

i want to  inform the public how i was cured of herpes  Virus by a Doctor called Dr ishiaku. i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on Herpes and i saw comment of people talking about how Doctor ishiaku cured them. I Was scared because i never believed in the Internet but i was convince to give him a try because i was having no hope of been cured of herpes so i decided to contact him on his email, i searched his email on net and i saw a lot of people testifying about his goodness. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without problem, my HERPES result came out negative. You can contact him on his
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Florence said...


I started on COPD Herbal treatment from Ultimate Health Home, the treatment worked incredibly for my lungs condition. I used the herbal treatment for almost 4 months, it reversed my COPD. My severe shortness of breath, dry cough, chest tightness gradually disappeared. Reach Ultimate Health Home via their website www.ultimatelifeclinic.com . I can breath much better and It feels comfortable!

Elizabeth Glen said...

I was married at 32 and immediately tried to get pregnant. When I was unable to conceive I had blood tests for fertility and was told that I had an FSH (follicle stimulating hormone) of 54 and would not be able to have children. Even though the doctors knew that I had been diagnosed with Hashimoto’s thyroiditis since age 25, no one bothered to check my thyroid levels. my TSH was measured at .001. My Synthroid dosage was lowered. a friend advise me to contact a spiritualist who help with fertility with his medicine, i collected his contact and explain my situation to him he prepared for me a herbal medicine which i took as describe by him. became pregnant very quickly, I had a successful pregnancy. I have my baby august 2017. to get pregnant at age 35 with my 2nd child in september 2019, thank you sir , this is his email contact if you require his help babaka.wolf@gmail.com or Facebook at priest.babaka

Tamara Barrow said...

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cure. I've seen the great importance of natural herbs and the wonderful
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on how they were cured of herpes, HIV, diabetics etc by Dr. voodoo herbal
medicine, so i decided to contact the doctor because i know nature has the
power to heal anything. I was diagnosed with HIV for the past 7 years but
Dr. voodoo cured me with his herbs and i referred my aunt and her husband
to him immediately because they were both suffering from herpes but to God
be the glory, they were cured too .I know is hard to believe but am a
living testimony. There is no harm trying herbs. He is also a spell caster,
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prosper and excel in life. Contact Dr voodoo on Whatsapp or call him
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