Thursday, May 21, 2009

Grey baby syndrome, Blue baby syndrome, Bronze baby syndrome, Carbon baby syndrome, Blueberry muffin baby syndrome – Decoded



Grey baby syndrome :

The grey baby syndrome is a rare condition almost exclusively seen in neonates and very young infants receiving high doses of CHLORAMPHENICOL.

Toxic blood levels of chloramphenicol occurs due to :

  • inadeqaute conjugation of chloramphenicol with glucuronic acid because of inadequate activity of glucuronyl transferase in the newborn liver and
  • decreased renal excretion of the unconjugated chloramphenicol  leads

The infant is cyanosed, is acidotic, has cold peripheries and has the signs of all of marked hyponia, poor feeding, vomiting, loose stools and a distended abdomen.

Bronze baby  syndrome:

When infants with cholestatic jaundice are exposed to phototherapy they may develop a greyish-brown discoloration of skin.

Probably due to accumulation of porphyrins & other metabolites (formed by action of phototherapy) in plasma of infants who develop cholestasis.Not all infants with cholestasis will develop it.

  1. Dark, grayish brown discoloration of skin
  2. May persist for months
  3. Associated with Conjugated Hyperbilirubinemia

Carbon baby syndrome:

Universal acquired melanosis is a rare form of hypermelanosis which was synonymously referred to as "Carbon baby".A form of progressive mucocutaneous pigmentation caused by singly dispersed melanosomes within keratinocytes.

Carbon baby syndrome

Blue baby syndrome:

Here blue baby implies blue due to cyanosis.

It can be due to:

  • cyanotic heart diseases or
  • methemoglobinemia.

Blueberry muffin baby syndrome:

Blueberry muffin baby is a term used to describe neonates whose skin resembles a blueberry muffin (i.e., the skin shows diffuse, dark blue to violaceous purpuric macules and papules). The spots represent dermal hematopoiesis and are a sign of serious systemic disease, most often congenital infection. The congenital infection most commonly associated with this appearance is congenital rubella.check this dermatology link for a detailed explanation.

blueberry blue2

    congenital viral infections TORCH acronym for congenital infections: toxoplasmosis, other (syphilis, parvovirus, and other viral), rubella (the commonest cause), cytomegalovirus, and herpes simplex.
    hematologic dyscrasias Hemolytic disease of the newborn (ABO or Rh incompatibility) and hereditary spherocytosis.
    Neoplastic disease


    Leukemia cutis

    Langerhans' cell histiocytosis

    Congenital rhabdomyosarcoma with cutaneous metastases

    cutaneous vascular anomalies.


teja ul said...

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MR Lakshmi said...

Reading Makes Your Child Smarter

Reading is known to have numerous benefits. It increases your world knowledge, enhances your vocabulary, and works to improve your reading comprehension abilities.

But did you know that reading can actually make you smarter?

In fact, reading not only can make a child smarter, the very act of reading can even help to compensate for modest levels of cognitive ability in children by building their vocabulary and general knowledge! This is a finding reported by researchers Cunningham and Stanovich in a report titled "What Reading Does For the Mind".

The simple fact here is that reading can make your child smarter, and that learning to read early on is directly linked to later success in life.

1) Did you know that your child's vocabulary at 3 years old predicts his or her grade one reading success? [1]

2) Did you know that vocabulary and reading ability in first grade strongly predicts grade 11 outcomes? [2]

3) Did you know that your child's reading skill in grade 3 directly influences high school graduation? Studies have found that children who cannot read proficiently by grade 3 are four times more likely to leave school without a diploma than proficient readers! [3]

>> Give your child the best possible head start. Teach your child to read today. Click here to learn how.

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I can understand if you find that hard to believe... In fact, I had a difficult time believing it myself as well... that is, until I saw the videos they posted documenting the reading progress of the their children - not to mention all the videos other parents have sent in showcasing their children's reading progress after using the Children Learning Program. After learning more about their methods and techniques, it became clear how it's possible to teach young children to read effectively.

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>> Click here now to watch the videos and start teaching your child to read.

1. Vocabulary Development and Instruction: A Prerequisite for School Learning
Andrew Biemiller, University of Toronto

2. Early reading acquisition and its relation to reading experience and ability 10 years later.
Cunningham AE, Stanovich KE.

3. Double Jeopardy How Third-Grade Reading Skills and Poverty Influence High School Graduation
Donald J. Hernandez, Hunter College and the Graduate Center,

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